Heck W, Wübken G, Marcus I
Monatsschr Kinderheilkd (1902). 1976 Oct;124(10):694-8.
After contact with a rabies-infected rabbit, 31 Persons were submitted to complete vaccination treatment with duck embryo vaccine, comprising of injections of 1.0 ml each every fast night and two booster injections of 1.0 ml each, which were administered 10 and 20 days, respectively, after the end of the 14 days' vaccination series. After performance of intracutaneous and ophthalmic tests, 18 children received heterologous rabies immunserum (Behring) in a dose of 0.2 ml per kg of body weight before the beginning of the vaccination series. Six weeks after the start of the vaccination series neutralizing and complement-fixing antibodies (rate of conversion 100 per cent) were detected in all patients. The mean titre of neutralizing antibodies (mouse test 200 LD 50 Fixed virus, strain CVS) amounted to 1:140, that of complement-fixing antibodies to 1:41. Severe incompatibility reactions were not observed. Outpatient treatment with duck embryo vaccine therefore seems to be fully justified.
在接触一只感染狂犬病的兔子后，31人接受了鸭胚疫苗的全程接种治疗，包括每晚注射1.0毫升，共注射14天，之后分别在第10天和第20天进行两次1.0毫升的加强注射。在进行皮内和眼部测试后，18名儿童在接种系列开始前接受了异源狂犬病免疫血清（贝林），剂量为每公斤体重0.2毫升。接种系列开始六周后，在所有患者中均检测到中和抗体和补体结合抗体（转化率100%）。中和抗体的平均滴度（小鼠试验，200 LD 50固定病毒，CVS株）为1:140，补体结合抗体的平均滴度为1:41。未观察到严重的不相容反应。因此，鸭胚疫苗的门诊治疗似乎完全合理。
