Costa N, Maquis P M
Faculty of Mechanical Engineering, Department of Materials Engineering, State University of Campinas, SP, Brazil.
Med Eng Phys. 1998 Nov;20(8):602-6. doi: 10.1016/s1350-4533(98)00056-3.
Most ceramics used in surgical implantation are better tolerated by the body environment than other biomaterials, particularly metals. However, the broader application of ceramics is limited because they are brittle and prone to catastrophic failure. By contrast. naturally produced ceramic organic biocomposites can possess mechanical properties which make them suitable for use as biomaterials. An example would be the mollusc shell, where an inorganic phase grows onto a charged and organised organic template. This natural biomineralization provides a calcium carbonate phase with satisfactory mechanical properties appropriate for surgical implantation. It is reported how Langmuir Blodgett films have been used as organic templates for calcium phosphate crystallization. Three different Langmuir Blodgett Films: omega tricosenoic acid, stearic acid and octadecylamine have been investigated. The Langmuir Blodgett Films produced had methyl (CH3) and calcium carboxylate (CaCOO) as functional groups. Atomic force microscopy and scanning electron microscopy shows that calcium phosphate crystallization occurs in a similar manner to natural biomineralization. The calcium carboxylate head group appears to have a physical influence on the morphology and distribution of the calcium phosphate crystals. Under the experimental conditions tested, the calcium carboxylate functional head group controls calcium phosphate crystallization by a biomimetic approach. This study strongly suggests that this approach has the potential for producing high performance ceramics comparable with those made by mollusc shells.
与其他生物材料，尤其是金属相比，大多数用于外科植入的陶瓷在人体环境中具有更好的耐受性。然而，陶瓷的广泛应用受到限制，因为它们易碎且容易发生灾难性故障。相比之下，天然产生的陶瓷有机生物复合材料可以具有使其适合用作生物材料的机械性能。一个例子是软体动物壳，其中无机相生长在带电且有组织的有机模板上。这种天然生物矿化提供了具有适合外科植入的令人满意机械性能的碳酸钙相。本文报道了如何将朗缪尔-布洛杰特膜用作磷酸钙结晶的有机模板。研究了三种不同的朗缪尔-布洛杰特膜：ω-二十三碳烯酸、硬脂酸和十八烷基胺。所制备的朗缪尔-布洛杰特膜具有甲基（CH3）和羧酸钙（CaCOO）作为官能团。原子力显微镜和扫描电子显微镜表明，磷酸钙结晶的发生方式与天然生物矿化相似。羧酸钙头基似乎对磷酸钙晶体的形态和分布有物理影响。在所测试的实验条件下，羧酸钙官能头基通过仿生方法控制磷酸钙结晶。这项研究强烈表明，这种方法有潜力生产出与软体动物壳制成的陶瓷相媲美的高性能陶瓷。
