Liu C M, Sheen T S, Ko J Y, Shun C T
Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Br J Cancer. 1999 Jan;79(2):360-2. doi: 10.1038/sj.bjc.6690057.
The sera from patients with nasopharyngeal carcinoma (n = 30), oral carcinoma (n = 22) and laryngeal carcinoma (n = 22) was extracted before treatment. The concentration of circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) was measured by enzyme-linked immunoassay and compared with those from normal subjects (n = 20). The concentration of circulating ICAM-1, E-selectin and VCAM-1 was significantly increased in nasopharyngeal carcinoma. Correspondingly, VCAM-1 and E-selectin were significantly increased in laryngeal carcinoma, whereas only E-selectin was elevated in oral carcinoma. The concentrations of these adhesion molecules did not significantly differ with respect to the early and late stages of these carcinomas. Elevated levels of soluble adhesion molecules in the sera of cancer patients at three different head and neck regions, although appearing to be implicated in these tumour formations, may be unrelated to tumour progression.
在治疗前采集了30例鼻咽癌患者、22例口腔癌患者和22例喉癌患者的血清。采用酶联免疫吸附测定法检测循环细胞间黏附分子1（ICAM-1）、E-选择素和血管细胞黏附分子1（VCAM-1）的浓度，并与20例正常受试者的浓度进行比较。鼻咽癌患者循环ICAM-1、E-选择素和VCAM-1的浓度显著升高。相应地，喉癌患者的VCAM-1和E-选择素显著升高，而口腔癌患者仅E-选择素升高。这些黏附分子的浓度在这些癌症的早期和晚期没有显著差异。三个不同头颈区域癌症患者血清中可溶性黏附分子水平升高，尽管似乎与这些肿瘤形成有关，但可能与肿瘤进展无关。
