Acute leptomeningeal reaction to the subarachnoid injection of ethyl iodophenylundecylate in dogs.

The effects of the subarachnoid injection of ethyl iodophenylundecylate were observed serially in dogs. The results of neurologic examination and cerebrospinal fluid analysis as well as the gross and histologic apppearance of the brain and spinal cord were evaluated. In 8 dogs, progressive nonpurulent leptomeningitis peaked in 5 days and regressed thereafter. The reaction appeared to be related to the physical properties of ethyl iodophenylundecylate.