Kalechstein A D, Hinkin C H, van Gorp W G, Castellon S A, Satz P
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Neuropsychiatric Institute and Hospital, USA.
J Clin Exp Neuropsychol. 1998 Aug;20(4):529-35. doi: 10.1076/jcen.20.4.529.1473.
Forty-three homosexual/bisexual males with HIV-1 infection participated in a study that sought to determine: (1) whether increased levels of self-reported depressive symptomatology were associated with poorer performance on episodic or procedural memory tasks, (2) the relative strength of association between the affective/cognitive or somatic symptoms of depression and memory deficits and level of immunosuppression, and (3) whether increased depression or neuropsychological deficits are associated with degree of immunosuppression. Linear regression analyses revealed that increased affective/cognitive symptomatology was correlated with poorer performance on a procedural memory task, but was not correlated with performance on an episodic memory task or degree of immunosuppression. In contrast, somatic symptoms showed the strongest association with level of immunosuppression, but were not correlated with performance on the memory tasks. These findings underscore the complex interplay between neuropsychiatric and neuropsychological symptomatology in HIV-1 infection.
43名感染了HIV-1的同性恋/双性恋男性参与了一项研究，该研究旨在确定：（1）自我报告的抑郁症状水平升高是否与情景记忆或程序性记忆任务表现较差有关；（2）抑郁的情感/认知或躯体症状与记忆缺陷及免疫抑制水平之间关联的相对强度；（3）抑郁增加或神经心理学缺陷是否与免疫抑制程度有关。线性回归分析显示，情感/认知症状增加与程序性记忆任务表现较差相关，但与情景记忆任务表现或免疫抑制程度无关。相比之下，躯体症状与免疫抑制水平关联最强，但与记忆任务表现无关。这些发现强调了HIV-1感染中神经精神症状与神经心理学症状之间复杂的相互作用。
