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Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal.

作者信息

Seeber U, Kuschinsky K

出版信息

Arch Toxicol. 1976 Aug 18;35(4):247-53. doi: 10.1007/BF00570266.

DOI:10.1007/BF00570266
PMID:989295
Abstract

Repeated administrations of ethanol and of phenobarbital to rats led to characteristic withdrawal symptoms when the drug had been stopped. Since both drugs affect brain dopamine metabolism, the postjunctional sensitivity to dopamine in the corpora striata was tested during ethanol or phenobarbital withdrawal. This was done by studying the dopamine-sensitive adenylate cyclase in homogenates of the copora striata of ethanol- or phenobarbital-dependent rats. The results demonstrated a slight postjunctional subsensitivity to dopamine in withdrawal from both ethanol and phenobarbital. Both drugs, when added in vitro, did not affect the postjunctionsl sensitivity to dopamine. The results do not support the hypothesis, at least not in the case of dopamine, that a postjunctional supersensitivity to neurotransmitters is important for withdrawal symptoms after chronic administration of drugs inducing physical dependence.

摘要

相似文献

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本文引用的文献

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A rapid technique for producing ethanol dependence in the rat.一种在大鼠中产生乙醇依赖的快速技术。
Pharmacol Biochem Behav. 1974 Nov-Dec;2(6):831-4. doi: 10.1016/0091-3057(74)90117-8.
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Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines.在用干扰儿茶酚胺突触功能的药物进行长期治疗后，对阿扑吗啡的行为超敏反应。
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Alterations of dopaminergic neurotransmission after chronic morphine treatment: pre- and postjunctional studies in striatal tissue.
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Dopaminergic supersensitivity after neuroleptics: time-course and specificity.抗精神病药物后的多巴胺能超敏反应：时间进程与特异性
Psychopharmacology (Berl). 1978 Dec 15;60(1):1-11. doi: 10.1007/BF00429171.
巴比妥类药物和甲丙氨酯：中枢多巴胺和去甲肾上腺素神经元系统儿茶酚胺周转率的降低及固定应激的影响
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Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".大鼠脑尾状核中对多巴胺敏感的腺苷酸环化酶及其与“多巴胺受体”的相似性。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9. doi: 10.1073/pnas.69.8.2145.
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Enhancement of dopamine-stimulated adenylate cyclase activity in rat caudate after lesions in substantia nigra: evidence for denervation supersensitivity.黑质损伤后大鼠尾状核中多巴胺刺激的腺苷酸环化酶活性增强：去神经超敏反应的证据。
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Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.6-羟基多巴胺诱导黑质-纹状体多巴胺系统变性后的突触后超敏反应。
Acta Physiol Scand Suppl. 1971;367:69-93. doi: 10.1111/j.1365-201x.1971.tb11000.x.
8
A protein binding assay for adenosine 3':5'-cyclic monophosphate.一种用于检测3':5'-环磷酸腺苷的蛋白质结合测定法。
Proc Natl Acad Sci U S A. 1970 Sep;67(1):305-12. doi: 10.1073/pnas.67.1.305.
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Suppression by dopamine-agonists of the ethanol-induced stimulation of locomotor activity and brain dopamine synthesis.
Naunyn Schmiedebergs Arch Pharmacol. 1974;283(2):117-28. doi: 10.1007/BF00501138.
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Dopamine-sensitive adenylate cyclase in mammalian brain: a possible site of action of antipsychotic drugs.哺乳动物脑中对多巴胺敏感的腺苷酸环化酶：抗精神病药物的一个可能作用位点。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1113-7. doi: 10.1073/pnas.71.4.1113.