Strocchi P, Gandolfi O, Montanaro N
Arzneimittelforschung. 1976;26(3):419-21.
Preventive activity of N-ethyl-2(2-methoxy-5-sulfamido-benzamidomethyl)-pyrrolidine (sulpiride, Dobren) upon restraint ulcer has been studied using two strains of rats (Wistar and Sprague-Dawley) treated with single or repeated administration of 5, 10, 20, 40 mg/kg i.p. of the drug. Wistar strain was shown to be less sensitive to the ulcerogenic procedure and a significant preventive effect of sulpiride occurred only at the dose of 10 mg/kg i.p. In the Sprague-Dawley strain a preventive effect was present not only at this dose but also at the dose of 20 mg/kg i.p. and 5 mg/kg i.p., the latter dose giving the greatest effect. Animals receiving the dose of 40 mg/kg i.p. did not differ significantly from the control in both strains. Results are discussed in relation to possible changes of the cerebral mono-amine turnover during the establishment of stress ulcer, particularly in terms of restoration of the balance between dopamine (DA) and norepinephrine (NE) neuronal activity.
使用两种品系的大鼠（Wistar和Sprague-Dawley），腹腔注射5、10、20、40mg/kg剂量的N-乙基-2(2-甲氧基-5-氨磺酰基-苯甲酰胺甲基)-吡咯烷（舒必利，Dobren），单次或重复给药，研究了其对束缚性溃疡的预防作用。结果显示，Wistar品系大鼠对致溃疡程序的敏感性较低，舒必利仅在腹腔注射10mg/kg剂量时具有显著的预防作用。在Sprague-Dawley品系中，不仅在该剂量下，而且在腹腔注射20mg/kg和5mg/kg剂量时均有预防作用，后者剂量的效果最佳。腹腔注射40mg/kg剂量的动物在两个品系中与对照组相比均无显著差异。结合应激性溃疡形成过程中脑单胺代谢可能的变化，特别是多巴胺（DA）和去甲肾上腺素（NE）神经元活动平衡的恢复，对结果进行了讨论。
