Gepdiremen Akçahan, Süleyman Halis
Atatürk University, Medical Faculty, Department of Pharmacology, TR-25240 Erzurum, Turkey.
Pol J Pharmacol. 2003 Mar-Apr;55(2):209-12.
Stress has an important role in the induction of gastroduodenal injury. It was reported that oxygen free radicals played a role in the pathogenesis of this injury. Although some other antioxidant compounds and calcium channel blockers were examined in ulcer models, salicylate has not been tested for its gastroprotective effect in ulcer models by now. In the present study, intraperitoneal administration of 10, 25 and 50 mg/kg of salicylate dose-dependently prevented ulcer formation in obligatory immobilization model in rats. This protective effect of salicylate was found more potent than that of ranitidine for all doses tested. As expected, peroral (by gavage) administration of salicylate at 50 mg/kg exacerbated the ulcer score, in comparison with the control.
应激在胃十二指肠损伤的诱发中起重要作用。据报道，氧自由基在这种损伤的发病机制中发挥作用。尽管在溃疡模型中对一些其他抗氧化化合物和钙通道阻滞剂进行了研究，但迄今为止水杨酸盐在溃疡模型中的胃保护作用尚未得到测试。在本研究中，腹腔注射10、25和50mg/kg水杨酸盐可剂量依赖性地预防大鼠强制固定模型中的溃疡形成。在所有测试剂量下，水杨酸盐的这种保护作用比雷尼替丁更强。正如预期的那样，与对照组相比，口服（通过灌胃）50mg/kg水杨酸盐会加重溃疡评分。
