Mattke D J, Wisuschil W
Arzneimittelforschung. 1976;26(5):946-50.
A pupilostatic method of measuring the pupillary diameter after standardized exclusion of retinal impulses is described. The pupil is photographed by a polaroid camera at a 1 : 2 scale. On the photographs the pupillary diameter is measured under a magnifying lens. We then present data of application of the method in a clinical experiment. The question we investigated was to determine physical effects of neuroleptic drugs in changes of the pupillary diameter. Our patients were 40 acute schizophrenics treated with two different neuroleptic drugs. It was found that already after a single dose of 1 mg 4'-fluora-4-[4-hydroxy-4-(4-chlorophenyl)-piperidyl-(1)]-butyrophenone (haloperidol) or 10 mg 2-chloro-11-(4-methyl-1-peperazinyl)-dibenz[b,f]-1,4-oxazepine (loxapine), respecitvely, a distinct change in pupillary diameter was measureable. The statistically significant differences in the effects of the two neuroleptics point as a further finding to the sensitivity of the developed method. This difference was paralleled by our clinical observation that loxapine showed more distinctly sedative effects in comparison with haloperidol.
描述了一种在视网膜冲动标准化排除后测量瞳孔直径的瞳孔测量方法。用宝丽来相机以1:2的比例拍摄瞳孔。在照片上，在放大镜下测量瞳孔直径。然后我们展示该方法在临床实验中的应用数据。我们研究的问题是确定抗精神病药物对瞳孔直径变化的物理影响。我们的患者是40名接受两种不同抗精神病药物治疗的急性精神分裂症患者。结果发现，分别单次服用1毫克4'-氟-4-[4-羟基-4-(4-氯苯基)-哌啶基-(1)]-丁酰苯（氟哌啶醇）或10毫克2-氯-11-(4-甲基-1-哌嗪基)-二苯并[b,f]-1,4-恶唑嗪（洛沙平）后，即可测量到瞳孔直径有明显变化。两种抗精神病药物效果的统计学显著差异进一步表明了所开发方法的敏感性。这种差异与我们的临床观察结果一致，即与氟哌啶醇相比，洛沙平的镇静作用更明显。
