Harris N L, Isaacson P G
Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.
Am J Clin Pathol. 1999 Jan;111(1 Suppl 1):S126-32.
Criteria for the diagnosis of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type differed among participants in the Society for Hematopathology Workshop. Some would accept any extranodal lymphoma that lacked features of another lymphoma type as MALT type, while others required the presence of all morphologic criteria. Criteria for the diagnosis of MALT-type lymphoma can be clinical, morphologic, and biologic, and the implications of making the diagnosis may dictate how restrictive the criteria for diagnosis should be. The morphologic definition of MALT lymphoma is a lymphoma that recapitulates the structure of the Peyer's patch. The clinical definition is an indolent extranodal lymphoma that tends to remain localized or to recur in other extranodal sites, with a potential for cure with local therapy. The biologic definition is unknown, but it includes an antigen-stimulated B cell with a special relationship to epithelial tissues and germinal centers. For clinical purposes, exclusion of one of the other types of small B-cell lymphoma may be sufficient to dictate treatment. For investigation and further understanding of lymphomas, however, a more restrictive definition should be used, since there may be other small B-cell lymphomas not yet described.
黏膜相关淋巴组织（MALT）型低度B细胞淋巴瘤的诊断标准在血液病理学协会研讨会上的参会者中存在差异。一些人会将任何缺乏其他淋巴瘤类型特征的结外淋巴瘤视为MALT型，而另一些人则要求具备所有形态学标准。MALT型淋巴瘤的诊断标准可以是临床、形态学和生物学方面的，做出诊断的意义可能决定诊断标准应具有多大的限制性。MALT淋巴瘤的形态学定义是一种重现派伊尔结结构的淋巴瘤。临床定义是一种惰性结外淋巴瘤，倾向于局限于局部或在其他结外部位复发，有可能通过局部治疗治愈。生物学定义尚不清楚，但包括与上皮组织和生发中心有特殊关系的抗原刺激B细胞。出于临床目的，排除其他类型的小B细胞淋巴瘤之一可能足以指导治疗。然而，为了对淋巴瘤进行研究和进一步了解，应使用更具限制性的定义，因为可能存在尚未描述的其他小B细胞淋巴瘤。
