从淋巴细胞间质性肺炎到肺黏膜相关淋巴组织淋巴瘤：一例伴有5年诊断困境的病例报告
From lymphocytic interstitial pneumonia to MALT lymphoma of lung: a case report with a 5-year diagnostic dilemma.
作者信息
Wu Wei, Zhou Jing, Di Li-Gai, Chen Hui
机构信息
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Medical University Xi'an, China.
出版信息
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9698-702. eCollection 2015.
Abstract
Lymphocytic interstitial pneumonia (LIP) and mucosa-associated lymphoid tissue (MALT) lymphoma of lung are all uncommon disorders of respiratory system. MALT lymphoma of lung is a distinct and unique subtype of marginal zone B-cell non-Hodgkin's lymphoma (NHL) characterized by malignant cells arising from extranodal sites. They are characteristic of exuberant lymphoid infiltration in pathological tissue. Therefore, in some cases, they are too similar in clinical manifestation, chest imaging and pathology to make differential diagnosis. Here, we report a 43-year-old woman who underwent a tough process for the final diagnosis. From this case, we could get a well understanding of difference between LIP and MALT lymphoma of lung.
摘要
淋巴细胞间质性肺炎（LIP）和肺黏膜相关淋巴组织（MALT）淋巴瘤均为呼吸系统的罕见疾病。肺MALT淋巴瘤是边缘区B细胞非霍奇金淋巴瘤（NHL）的一种独特亚型，其特征是恶性细胞起源于结外部位。它们在病理组织中具有丰富的淋巴细胞浸润特征。因此，在某些情况下，它们在临床表现、胸部影像学和病理学方面过于相似，难以进行鉴别诊断。在此，我们报告一名43岁女性，其最终诊断经历了艰难的过程。从这个病例中，我们可以很好地了解LIP和肺MALT淋巴瘤之间的差异。
相似文献
1
From lymphocytic interstitial pneumonia to MALT lymphoma of lung: a case report with a 5-year diagnostic dilemma.从淋巴细胞间质性肺炎到肺黏膜相关淋巴组织淋巴瘤：一例伴有5年诊断困境的病例报告
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9698-702. eCollection 2015.
2
Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report.伴有多发纯磨玻璃影的黏膜相关淋巴组织原发性结外边缘区淋巴瘤：一例报告
J Cardiothorac Surg. 2017 Jan 25;12(1):2. doi: 10.1186/s13019-017-0565-9.
3
Extranodal marginal zone lymphoma of MALT involving the lungs, the stomach, and the colon.累及肺、胃和结肠的黏膜相关淋巴组织结外边缘区淋巴瘤。
Lung Cancer. 2006 Dec;54(3):427-9. doi: 10.1016/j.lungcan.2006.07.008. Epub 2006 Sep 7.
4
[Primary pulmonary mucosa-associated lymphoid tissue lymphoma: a case report].[原发性肺黏膜相关淋巴组织淋巴瘤：一例报告]
Pneumonol Alergol Pol. 2015;83(1):45-9. doi: 10.5603/PiAP.2015.0006.
5
[Mucosa-associated lymphoid tissue lymphoma; report of two cases].[黏膜相关淋巴组织淋巴瘤；两例报告]
Kyobu Geka. 2004 Jan;57(1):75-9.
6
[Clinical characteristics and diagnosis of pulmonary mucosa-associated lymphoid tissue-derived (MALT) lymphoma: a retrospective analysis of 29 cases].肺黏膜相关淋巴组织来源（MALT）淋巴瘤的临床特征与诊断：29例回顾性分析
Zhonghua Zhong Liu Za Zhi. 2012 May;34(5):390-3. doi: 10. 3760/cma.j.issn.0253-3766.2012.05.017.
7
Primary pulmonary MALT lymphoma presenting as non-resolving pneumonia.表现为迁延不愈肺炎的原发性肺黏膜相关淋巴组织淋巴瘤
Adv Respir Med. 2017;85(4):202-205. doi: 10.5603/ARM.2017.0033.
8
[Pulmonary actinomycosis mimicking of mucosa-associated lymphoid tissue lymphoma by frozen section examination: report of a case].
Kyobu Geka. 2003 Feb;56(2):165-8.
9
10
Marginal zone B-cell non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type: imaging findings.黏膜相关淋巴组织型边缘区B细胞非霍奇金淋巴瘤：影像学表现
AJR Am J Roentgenol. 2008 Sep;191(3):921-30. doi: 10.2214/AJR.07.2629.
引用本文的文献
1
A case of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in a patient with a history of idiopathic lymphocytic interstitial pneumonia (iLIP).一名有特发性淋巴细胞间质性肺炎（iLIP）病史的患者发生肺黏膜相关淋巴组织（MALT）淋巴瘤的病例。
Gen Thorac Cardiovasc Surg Cases. 2025 May 9;4(1):24. doi: 10.1186/s44215-025-00208-3.
2
Primary lung mucosa-associated lymphoid tissue lymphoma accompanied by multiple sclerosis: case report and molecular diagnosis.原发性肺黏膜相关淋巴组织淋巴瘤伴多发性硬化：病例报告及分子诊断
Chin Med J (Engl). 2019 Jul 5;132(13):1625-1628. doi: 10.1097/CM9.0000000000000272.
3
A case report of lymphoid intestitial pneumonia in common variable immunodeficiency: Oligoclonal expansion of effector lymphocytes with preferential cytomegalovirus-specific immune response and lymphoproliferative disease promotion.普通可变免疫缺陷中淋巴样间质性肺炎的一例报告：效应淋巴细胞的寡克隆扩增伴巨细胞病毒特异性免疫反应及促进淋巴增殖性疾病
Medicine (Baltimore). 2017 Jun;96(23):e7031. doi: 10.1097/MD.0000000000007031.
本文引用的文献
1
Lymphocytic interstitial pneumonia as a manifestation of SLE and secondary Sjogren's syndrome.淋巴细胞性间质性肺炎作为系统性红斑狼疮和继发性干燥综合征的一种表现。
BMJ Case Rep. 2013 Aug 2;2013:bcr2013009598. doi: 10.1136/bcr-2013-009598.
2
Update on MALT lymphomas.黏膜相关淋巴组织淋巴瘤的最新进展。
Best Pract Res Clin Haematol. 2005 Mar;18(1):57-68. doi: 10.1016/j.beha.2004.08.003.
3
Interobserver variation in the histopathological assessment of malt/malt lymphoma: towards a consensus.
Blood Cells Mol Dis. 2005 Jan-Feb;34(1):6-16. doi: 10.1016/j.bcmd.2004.10.003.
4
CT-histologic correlation of the ATS/ERS 2002 classification of idiopathic interstitial pneumonias.美国胸科学会/欧洲呼吸学会2002年特发性间质性肺炎分类的CT与组织学相关性
Radiographics. 2003 Sep-Oct;23(5):1057-71. doi: 10.1148/rg.235035702.
5
Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.不同部位MALT淋巴瘤中t(11;18)(q21;q21)的可变频率：与胃MALT淋巴瘤中幽门螺杆菌CagA菌株显著相关。
Blood. 2003 Aug 1;102(3):1012-8. doi: 10.1182/blood-2002-11-3502. Epub 2003 Apr 3.
6
Pulmonary interstitial disease in Ig deficiency.免疫球蛋白缺乏症中的肺间质疾病
Chest. 2002 Nov;122(5):1594-603. doi: 10.1378/chest.122.5.1594.
7
Expression of CD10, CD75 and CD43 in MALT lymphoma and their usefulness in discriminating MALT lymphoma from follicular lymphoma and chronic gastritis.
Histopathology. 1999 Sep;35(3):209-15. doi: 10.1046/j.1365-2559.1999.00694.x.
8
What are the criteria for distinguishing MALT from non-MALT lymphoma at extranodal sites?区分结外部位黏膜相关淋巴组织（MALT）淋巴瘤与非MALT淋巴瘤的标准是什么？
Am J Clin Pathol. 1999 Jan;111(1 Suppl 1):S126-32.
9
Radiological appearances of lymphomas arising from mucosa-associated lymphoid tissue (MALT) in the lung.肺黏膜相关淋巴组织（MALT）淋巴瘤的放射学表现。
Clin Radiol. 1998 Apr;53(4):258-63. doi: 10.1016/s0009-9260(98)80123-2.
10
Diffuse low-grade B-cell lymphomas. Four clinically distinct subtypes defined by a combination of morphologic and immunophenotypic features.弥漫性低级别B细胞淋巴瘤。由形态学和免疫表型特征组合定义的四种临床不同亚型。
Am J Clin Pathol. 1993 Oct;100(4):373-85. doi: 10.1093/ajcp/100.4.373.
Zotero 插件