Lim A G, Langmead F L, Feakins R M, Rampton D S
Department of Gastroenterology, Royal London Hospital, Whitechapel, London, UK.
Gut. 1999 Feb;44(2):279-82. doi: 10.1136/gut.44.2.279.
The aetiology of ulcerative colitis is unknown. Two patients without pre-existing inflammatory bowel disease in whom end colostomy for faecal incontinence was complicated by diversion colitis in the defunctioned rectosigmoid colon, are described. In both instances, colitis with the clinical, colonoscopic, and microscopic features of ulcerative colitis developed about a year later in the previously normal in-stream colon proximal to the colostomy. These cases suggest that diversion colitis may be a risk factor for ulcerative colitis in predisposed individuals and that ulcerative colitis can be triggered by anatomically discontinuous inflammation elsewhere in the large intestine.
溃疡性结肠炎的病因尚不清楚。本文描述了两名既往无炎性肠病的患者，他们因大便失禁接受了末端结肠造口术，术后在失功能的直肠乙状结肠发生了改道性结肠炎。在这两个病例中，具有溃疡性结肠炎临床、结肠镜及显微镜特征的结肠炎大约在一年后出现在造口近端之前正常的顺行结肠中。这些病例表明，改道性结肠炎可能是易感个体患溃疡性结肠炎的一个危险因素，且溃疡性结肠炎可能由大肠其他部位解剖学上不连续的炎症引发。
