Denson K W
Thromb Haemost. 1976 Apr 30;35(2):314-23.
The clotting of C. V. Helleri plasma is not accelerated by the factor X activator or thrombin-like enzymes from its own venom. Clotting of the plasma is accelerated by the factor Xactivator from Russell's viper venom, but not by the thrombin-like enzyme from Agkistrodon Rhodostoma venom ("Arvin"). The prothrombin activator from the Taipan venom clots C.V. Helleri plasma equally well as human plasma, but the thrombin which is produced has a marked specificity for its own fibrinogen, and clots bovine fibrinogen more slowly. C.V. Helleri plasma contains an inhibitor which progressively inactivates bovine factor Xa and thrombin, but the inhibitor is not potentiated by heparin. The slow, protracted clotting of the snake plasma either alone or when mixed with human plasma or bovine fibrinogen suggests that this inhibitor may interfere with the polymerisation of fibrin monomer.
海氏蝰蛇（C. V. Helleri）血浆的凝血过程不会被其自身毒液中的X因子激活剂或类凝血酶加速。其血浆的凝血过程会被锯鳞蝰蛇毒液中的X因子激活剂加速，但不会被红口蝮蛇毒液（“安克洛酶”）中的类凝血酶加速。太攀蛇毒液中的凝血酶原激活剂使海氏蝰蛇血浆凝固的效果与人类血浆相当，但产生的凝血酶对其自身纤维蛋白原有显著的特异性，使牛纤维蛋白原凝固得更慢。海氏蝰蛇血浆含有一种抑制剂，该抑制剂会逐渐使牛Xa因子和凝血酶失活，但肝素不会增强这种抑制剂的作用。单独的蛇血浆或与人类血浆或牛纤维蛋白原混合时的缓慢、持久的凝血过程表明，这种抑制剂可能会干扰纤维蛋白单体的聚合。
