Teien A N, Abildgaard U
Thromb Haemost. 1976 Jun 30;35(3):592-7.
Of 1068 blood samples referred for evaluation of the haemostatic mechanism 135 contained heparin as judged by the polybrene titration method. Of the 57 samples with a heparin concentration in the defined therapeutic range, 65 per cent had APTT values in the "therapeutic range". Of the samples from patients who had not received any anticoagulant, 213 (24 per cent) had prolonged APTT, and 48 of these samples had APTT values in the "therapeutic range" for heparin therapy. It is suggested that the APTT test is of limited value in monitoring heparin therapy.
在送检以评估止血机制的1068份血样中，采用鱼精蛋白滴定法判断有135份含有肝素。在肝素浓度处于规定治疗范围内的57份样本中，65%的活化部分凝血活酶时间（APTT）值处于“治疗范围内”。在未接受任何抗凝剂治疗的患者样本中，213份（24%）的APTT延长，其中48份样本的APTT值处于肝素治疗的“治疗范围内”。提示APTT检测在监测肝素治疗方面价值有限。
