糖尿病患者的小肠转运
Small intestinal transit in diabetics.
作者信息
Scarpello J H, Greaves M, Sladen G E
出版信息
Br Med J. 1976 Nov 20;2(6046):1225-6. doi: 10.1136/bmj.2.6046.1225.
Abstract
Small intestinal transit was assessed in diabetic patients and healthy controls by measuring the breath hydrogen appearance time after the ingestion of lactulose. Transit in diabetics with autonomic neuropathy was significantly slower than in diabetics without neuropathy and controls. Delayed transit is probably due to vagal denervation. These slower transit times would allow bacteria to proliferate, which might explain why some diabetics have diarrhoea. The test cannot be used in patients with bacteria in the small bowel because these may metabolise lactulose and release hydrogen prematurely.
摘要
通过测量摄入乳果糖后呼出氢气的出现时间，对糖尿病患者和健康对照者的小肠转运情况进行了评估。伴有自主神经病变的糖尿病患者的转运速度明显慢于无神经病变的糖尿病患者和健康对照者。转运延迟可能是由于迷走神经去神经支配。这些较慢的转运时间会使细菌增殖，这可能解释了为什么一些糖尿病患者会出现腹泻。该检测不能用于小肠中有细菌的患者，因为这些细菌可能会代谢乳果糖并过早释放氢气。
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