Fleming G M, Kleinerman J
Arch Pathol Lab Med. 1978 Sep;102(9):483-9.
The effects of prior sensitization with killed H37Ra tubercle bacilli on the pulmonary reaction to intravenous (IV) challenge with complete Freund's adjuvant (CFA) have been studied and were compared to reactions in nonsensitized CFA-challenged controls. Rabbits that died within 24 hours of challenge demonstrated acute arteritis prior to granuloma formation. Sensitized rabbits had a greater number of exudative cells in the pulmonary lavage fluid and a larger volume of parenchymal infiltrate than did comparable, nonsensitized controls at two and eight weeks. The exudate and infiltrate were diminished in both sensitized and nonsensitized rabbits at eight weeks. An obliterative, granulomatous arteritis was observed in both sensitized and nonsensitized groups receiving IV CFA and was not affected by the state of sensitivation. Granulomatous and collagenous parenchymal lesions regress in both sensitized and nonsensitized groups between two and eight weeks.
已研究了用灭活的H37Ra结核杆菌预先致敏对静脉注射（IV）完全弗氏佐剂（CFA）后肺部反应的影响，并与未致敏的CFA激发对照组的反应进行了比较。在激发后24小时内死亡的兔子在肉芽肿形成之前表现出急性动脉炎。在第2周和第8周时，致敏兔子肺灌洗液中的渗出细胞数量更多，实质浸润体积比相应的未致敏对照组更大。在第8周时，致敏和未致敏兔子的渗出物和浸润均减少。在接受IV CFA的致敏和未致敏组中均观察到闭塞性肉芽肿性动脉炎，且不受致敏状态的影响。在第2周和第8周之间，致敏和未致敏组的肉芽肿性和胶原性实质病变均消退。
