饥饿和链脲佐菌素诱导糖尿病大鼠肝脏线粒体中3-羟基-3-甲基戊二酸的形成与利用

Formation and utilization of 3-hydroxy-3-methylglutarate in liver mitochondria of starved and streptozotocin-diabetic rats.

作者信息

Dena R, Fabbro M, Rigoni F

出版信息

Biochem J. 1978 Jun 15;172(3):371-5. doi: 10.1042/bj1720371.

DOI:10.1042/bj1720371

PMID:99138

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1185710/

Abstract

Kidney and liver mitochondria of rat, rabbit and guinea pig are able to transform 3-hydroxy-3-methylglutarate into acetoacetate, whereas ox liver mitochondria and rat mitochondria of heart, diaphragm and brain do not exhibit such an activity. Starvation and streptozotocin treatment decreases the formation of acetoacetate from 3-hydroxy-3-methylglutarate. Addition of acetoacetate and succinate to the incubation media of mitochondria results in a decrease in the transformation of 3-hydroxy-3-methylglutarate into acetoacetate. A 3-hydroxy-3-methylglutaryl-CoA hydrolase is present in rat liver mitochondria; the activity does not show appreciable changes after starvation or streptozotocin treatment.

摘要

大鼠、兔子和豚鼠的肾脏及肝脏线粒体能够将3-羟基-3-甲基戊二酸转化为乙酰乙酸，而牛肝线粒体以及大鼠心脏、膈肌和脑的线粒体则不具备这种活性。饥饿和链脲佐菌素处理会减少由3-羟基-3-甲基戊二酸生成乙酰乙酸的过程。向线粒体孵育介质中添加乙酰乙酸和琥珀酸会导致3-羟基-3-甲基戊二酸向乙酰乙酸的转化减少。大鼠肝脏线粒体中存在一种3-羟基-3-甲基戊二酰辅酶A水解酶；饥饿或链脲佐菌素处理后，该酶活性未表现出明显变化。

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

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