Wall E M, Cao J X, Upton C
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
Int Rev Immunol. 1998;17(1-4):121-55. doi: 10.3109/08830189809084490.
Viruses and the immune system have been competitors throughout their co-evolution. It is therefore not surprising that the viruses in circulation today possess a variety of strategies to counteract those aspects of the immune system that are involved in virus clearance. Examination of these virus encoded functions provides an important view of immune function and an appreciation of the complexity of the virus-host interaction. It is clear that viruses, seeking to subvert the immune system, have become adept in blocking the communication channels of the immune system. There are numerous examples of viral proteins that target the cytokine networks, disrupting the processes by which the delicately balanced immune system is regulated. This review focuses on the gene products of poxviruses, adenoviruses and herpesviruses that function primarily as immune-modulators.
在病毒与免疫系统共同进化的过程中，二者一直是相互竞争的关系。因此，如今传播的病毒具备多种策略来对抗免疫系统中参与病毒清除的那些方面，这并不奇怪。对这些病毒编码功能的研究为免疫功能提供了重要视角，也让我们认识到病毒与宿主相互作用的复杂性。很明显，试图颠覆免疫系统的病毒已经擅长阻断免疫系统的通讯渠道。有许多病毒蛋白靶向细胞因子网络的例子，这些蛋白破坏了精细平衡的免疫系统的调节过程。本综述聚焦于主要作为免疫调节剂发挥作用的痘病毒、腺病毒和疱疹病毒的基因产物。
