Colman R J, Lane M A, Binkley N, Wegner F H, Kemnitz J W
Wisconsin Regional Primate Research Center and Department of Anthropology, University of Wisconsin, Madison 53715-1299, USA.
Bone. 1999 Jan;24(1):17-23. doi: 10.1016/s8756-3282(98)00147-1.
Age-related bone loss in men is receiving increased attention. In light of this, animal models for male bone loss are desirable. This study examined the effects of age and osteoarthritis (OA) on bone mineral content (BMC), bone mineral density (BMD), and markers of bone turnover and skeletal relevance in 56 male rhesus monkeys 4-34 years of age. BMC and BMD increased at all sites from 4 to 10 years of age. Male rhesus monkeys reach peak bone mass at approximately 10 years of age after which bone mass is lower at the lateral spine and distal radius. Markers of bone turnover (osteocalcin and carboxyterminal telopeptide of type I collagen [ICTP]) decreased with age. There was no relationship between PTH, 25-hydroxyvitamin D, FSH, or testosterone and age. With advancing age, the prevalence of lumbar spine OA increases dramatically, masking decreases in posteroanterior spine bone mass that are clear in the lateral projection. These data suggest that male rhesus monkeys sustain age-related bone loss in the absence of nutritional or gonadal steroid deficiencies. These animals may prove useful in studying the mechanisms of age-related bone loss.
男性与年龄相关的骨质流失正受到越来越多的关注。鉴于此，雄性骨质流失的动物模型是很有必要的。本研究在56只4至34岁的雄性恒河猴中，研究了年龄和骨关节炎（OA）对骨矿物质含量（BMC）、骨矿物质密度（BMD）以及骨转换标志物和骨骼相关性的影响。从4岁到10岁，所有部位的BMC和BMD均有所增加。雄性恒河猴大约在10岁时达到峰值骨量，此后腰椎和桡骨远端的骨量较低。骨转换标志物（骨钙素和I型胶原羧基末端肽[ICTP]）随年龄增长而下降。甲状旁腺激素（PTH）、25-羟基维生素D、促卵泡激素（FSH）或睾酮与年龄之间没有关系。随着年龄的增长，腰椎OA的患病率急剧增加，掩盖了后前位脊柱骨量的减少，而这在侧位投影中是明显的。这些数据表明，雄性恒河猴在没有营养或性腺类固醇缺乏的情况下会出现与年龄相关的骨质流失。这些动物可能在研究与年龄相关的骨质流失机制方面很有用。
