Black A, Tilmont E M, Handy A M, Scott W W, Shapses S A, Ingram D K, Roth G S, Lane M A
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, MD, USA.
Bone. 2001 Mar;28(3):295-302. doi: 10.1016/s8756-3282(00)00452-x.
Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models. We used dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD), bone mineral content (BMC), and projected area (PA) at four skeletal sites over 4 years in 20 premenopausal female (8-23 years) and 29 male (8-27 years) rhesus monkeys (Macaca mulatta). Forearm BMD declined with age in both male and female monkeys. Lean mass was positively associated with BMD at all sites in males and with the distal radius in females. Serum osteocalcin declined and urinary cross-links increased with age in males but not females. Serum 25-hydroxyvitamin D concentrations decreased with age in females, and a similar trend was observed in males. In conclusion, an age-related decline in forearm BMD was observed in male and female rhesus monkeys. Total body BMC declined over time in older females, with a similar trend in males. Changes in markers of bone turnover with age were also observed in male monkeys. The results of this longitudinal study suggest that the rhesus monkey is a potential model for age-related changes in the human skeleton.
衰老与男性和绝经前女性的骨质逐渐流失有关，女性在绝经后骨质流失速度加快。尽管许多研究调查了手术导致雌激素缺乏引起的骨质流失，但对于动物模型中正常的与年龄相关的骨量变化知之甚少。我们使用双能X线吸收法（DXA）在4年时间里测量了20只绝经前雌性（8 - 23岁）和29只雄性（8 - 27岁）恒河猴（猕猴）四个骨骼部位的骨矿物质密度（BMD）、骨矿物质含量（BMC）和投影面积（PA）。雄性和雌性猴子的前臂骨密度均随年龄下降。在雄性中，瘦体重与所有部位的骨密度呈正相关，在雌性中与桡骨远端呈正相关。雄性血清骨钙素随年龄下降，尿交联物随年龄增加，而雌性则不然。雌性血清25 - 羟维生素D浓度随年龄降低，雄性也观察到类似趋势。总之，在雄性和雌性恒河猴中均观察到与年龄相关的前臂骨密度下降。老年雌性的全身骨矿物质含量随时间下降，雄性也有类似趋势。在雄性猴子中也观察到骨转换标志物随年龄的变化。这项纵向研究的结果表明，恒河猴是人类骨骼与年龄相关变化的潜在模型。
