Champ J E, Binkley N, Havighurst T, Colman R J, Kemnitz J W, Roecker E B
Wisconsin Regional Primate Research Center, Madison, USA.
Bone. 1996 Nov;19(5):485-92. doi: 10.1016/s8756-3282(96)00243-8.
Dual-energy X-ray absorptiometry (DXA) can be used to assess bone mass in nonhuman primates; however, the changes in bone mineral across the lifespan have not been well described. The purpose of this cross-sectional study was to evaluate the effect of maturation and subsequent aging on bone mineral content (BMC) and bone size (two dimensional bone area) in female rhesus monkeys at sites analogous to those commonly evaluated in humans. Total body (n = 178) and lumbar spine (n = 167) DXA scans were performed on female rhesus monkeys aged 2.8 to 34.6 years. Radius scans (n = 86) were performed on monkeys aged 9.7 to 34.6 years. Measurement precision was comparable to that reported for humans. At all sites, BMC was highly correlated with bone area (p = 0.0001), which was positively correlated with both body weight (p < or = 0.002) and age (p < or = 0.08). Total body and lumbar spine BMC and bone area increased with maturation (p < 0.0001) until age 11 and then remained stable with further advancing age. There was little change in total body and lumbar spine area-adjusted BMC across the lifespan. At the radial sites, there were no significant changes in BMC or bone area with age, but the area-adjusted BMC and the weight- and area-adjusted BMC declined in older animals (p < 0.05). In conclusion, the female rhesus monkey does not attain peak bone mass until age 11. Significant bone loss at later ages was observed only at radial sites.
双能X线吸收法（DXA）可用于评估非人灵长类动物的骨量；然而，整个生命周期中骨矿物质的变化尚未得到充分描述。这项横断面研究的目的是评估成熟及随后的衰老对雌性恒河猴骨矿物质含量（BMC）和骨大小（二维骨面积）的影响，这些部位类似于人类通常评估的部位。对年龄在2.8至34.6岁的雌性恒河猴进行了全身（n = 178）和腰椎（n = 167）的DXA扫描。对年龄在9.7至34.6岁的猴子进行了桡骨扫描（n = 86）。测量精度与报道的人类测量精度相当。在所有部位，BMC与骨面积高度相关（p = 0.0001），骨面积与体重（p≤0.002）和年龄（p≤0.08）均呈正相关。全身和腰椎的BMC和骨面积随着成熟而增加（p < 0.0001），直到11岁，然后随着年龄的进一步增长保持稳定。在整个生命周期中，全身和腰椎面积校正后的BMC几乎没有变化。在桡骨部位，BMC或骨面积随年龄没有显著变化，但在老年动物中，面积校正后的BMC以及体重和面积校正后的BMC下降（p < 0.05）。总之，雌性恒河猴直到11岁才达到峰值骨量。仅在桡骨部位观察到后期有明显的骨质流失。
