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两种紫外线B辐射吸收型防晒霜对无毛小鼠紫外线辐射诱导的致癌作用、接触性超敏反应抑制及组织学变化的影响

The effects of two UVB radiation-absorbing sunscreens on UV radiation-induced carcinogenesis, suppression of the contact hypersensitivity response and histological changes in the hairless mouse.

作者信息

Kerr C

机构信息

Department of Animal Science, The University of Sydney, NSW, Australia.

出版信息

Mutat Res. 1998 Nov 9;422(1):161-4. doi: 10.1016/s0027-5107(98)00188-2.

DOI:10.1016/s0027-5107(98)00188-2
PMID:9920441
Abstract

The research summarised in this report suggests that the two UVB-absorbers, o-PABA and 2-EHMC, have different modes of protection against UV radiation-induced immunosuppression, carcinogenesis and histological alterations, that appear to be independent of their SPF values, within experimental limits. The UVB-absorber o-PABA appears offer a valuable level of protection against photocarcinogenesis.

摘要

本报告中总结的研究表明,两种紫外线B吸收剂,邻氨基苯甲酸(o-PABA)和二乙氨羟苯甲酰基苯甲酸己酯(2-EHMC),在实验范围内,对紫外线辐射引起的免疫抑制、致癌作用和组织学改变具有不同的保护模式,这些模式似乎与其防晒系数(SPF)值无关。紫外线B吸收剂邻氨基苯甲酸似乎对光致癌作用提供了有价值的保护水平。

相似文献

1
The effects of two UVB radiation-absorbing sunscreens on UV radiation-induced carcinogenesis, suppression of the contact hypersensitivity response and histological changes in the hairless mouse.两种紫外线B辐射吸收型防晒霜对无毛小鼠紫外线辐射诱导的致癌作用、接触性超敏反应抑制及组织学变化的影响
Mutat Res. 1998 Nov 9;422(1):161-4. doi: 10.1016/s0027-5107(98)00188-2.
2
Differential protection by two sunscreens from UV radiation-induced immunosuppression.两种防晒霜对紫外线辐射诱导的免疫抑制的差异保护作用。
J Invest Dermatol. 1991 Oct;97(4):624-8. doi: 10.1111/1523-1747.ep12483006.
3
Differential photoimmunoprotection by sunscreen ingredients is unrelated to epidermal cis urocanic acid formation in hairless mice.防晒成分的差异光免疫保护作用与无毛小鼠表皮顺式尿刊酸的形成无关。
J Invest Dermatol. 1994 Dec;103(6):801-6. doi: 10.1111/1523-1747.ep12413445.
4
Interaction of UVB-absorbing sunscreen ingredients with cutaneous molecules may alter photoimmune protection.吸收紫外线B的防晒成分与皮肤分子的相互作用可能会改变光免疫保护作用。
Photochem Photobiol. 2001 Dec;74(6):765-70. doi: 10.1562/0031-8655(2001)074<0765:iouasi>2.0.co;2.
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Sunscreen protection of contact hypersensitivity responses from chronic solar-simulated ultraviolet irradiation correlates with the absorption spectrum of the sunscreen.防晒剂对慢性模拟太阳紫外线照射引起的接触性超敏反应的防护作用与防晒剂的吸收光谱相关。
J Invest Dermatol. 1995 Sep;105(3):345-51. doi: 10.1111/1523-1747.ep12320580.
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Ultraviolet spectral energy differences affect the ability of sunscreen lotions to prevent ultraviolet-radiation-induced immunosuppression.紫外线光谱能量差异会影响防晒霜预防紫外线辐射引起的免疫抑制的能力。
Photochem Photobiol. 1996 Jun;63(6):874-84. doi: 10.1111/j.1751-1097.1996.tb09645.x.
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Effect of immunosuppressive agents and sunscreens on UV carcinogenesis in the hairless mouse.免疫抑制剂和防晒霜对无毛小鼠紫外线致癌作用的影响。
Aust J Exp Biol Med Sci. 1985 Dec;63 ( Pt 6):655-65. doi: 10.1038/icb.1985.69.
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Ultraviolet radiation-induced suppression of contact hypersensitivity in relation to padimate O and oxybenzone.
J Invest Dermatol. 1989 Mar;92(3):337-41. doi: 10.1111/1523-1747.ep12277156.
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Analysis of the protective effect of different sunscreens on ultraviolet radiation-induced local and systemic suppression of contact hypersensitivity and inflammatory responses in mice.不同防晒霜对紫外线辐射诱导的小鼠接触性超敏反应及炎症反应的局部和全身抑制的保护作用分析
J Invest Dermatol. 1993 Mar;100(3):254-9. doi: 10.1111/1523-1747.ep12469038.
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Does sunscreen protection from immunosuppression by solar UV radiation predict protection from photocarcinogenesis?
Redox Rep. 1999;4(6):309-10. doi: 10.1179/135100099101535160.

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