Reeve V E, Bosnic M, Boehm-Wilcox C, Ley R D
Department of Veterinary Pathology, University of Sydney, New South Wales, Australia.
J Invest Dermatol. 1991 Oct;97(4):624-8. doi: 10.1111/1523-1747.ep12483006.
A controversy has arisen concerning the ability of sunscreens to protect mice from the immunosuppressive effects of UV radiation. We have assessed the photoprotection in hairless mice of two sun protection factor (SPF)15 sunscreens containing different UVB (280-320-nm) absorbers, namely, octyl-N-dimethyl-p-aminobenzoate (o-PABA) or 2-ethylhexyl-p-methoxycinnamate (2-EHMC). Following three minimum erythemal exposures to UV radiation, both systemic suppression of contact hypersensitivity to 2,4-dinitrofluorobenzene and induction of susceptibility to transplanted UV radiation-induced tumor cells was established. Topically applied 2-EHMC sunscreen protected totally from both forms of immunosuppression, but the o-PABA sunscreen failed to protect, although both sunscreens were equally effective in protection from UV radiation-induced erythema and edema.
关于防晒霜能否保护小鼠免受紫外线辐射免疫抑制作用的问题引发了一场争议。我们评估了两种防晒系数（SPF）为15、含有不同中波紫外线（280 - 320纳米）吸收剂的防晒霜对无毛小鼠的光保护作用，这两种吸收剂分别是辛酯 - N - 二甲基 - 对氨基苯甲酸酯（邻氨基苯甲酸辛酯）或2 - 乙基己基 - 对甲氧基肉桂酸酯（桂皮酸盐）。在对紫外线进行三次最小红斑量照射后，既确定了对2,4 - 二硝基氟苯接触性超敏反应的全身抑制，也确定了对移植的紫外线辐射诱导肿瘤细胞易感性的诱导。局部涂抹桂皮酸盐防晒霜能完全防止这两种免疫抑制形式，但邻氨基苯甲酸辛酯防晒霜未能起到保护作用，尽管两种防晒霜在防止紫外线辐射引起的红斑和水肿方面同样有效。
