Averbuch-Heller L, Stahl J S, Hlavin M L, Leigh R J
Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, OH, USA.
Neurology. 1999 Jan 1;52(1):185-8. doi: 10.1212/wnl.52.1.185.
Square-wave jerks (SWJs) are small, inappropriate saccades that intrude on steady fixation by taking the eye away from the target and then returning it after approximately 200 msec. The pathophysiology of SWJs is unknown; they have not been attributed to any specific lesion. We found that unilateral pallidotomy substantially increased the frequency of SWJs in three patients with Parkinson's disease. This effect is likely due to imbalance in the fixation system caused by asymmetric reactivation of prefrontal cortex via ascending thalamocortical projections. Alternatively, disruption of nigral projections to the superior colliculus might be responsible.
方波急跳（SWJs）是一种微小的、不适当的扫视运动，通过将眼睛移离目标，然后在大约200毫秒后再将其移回，从而干扰稳定的注视。SWJs的病理生理学尚不清楚；它们尚未归因于任何特定病变。我们发现，单侧苍白球切开术显著增加了三名帕金森病患者的SWJs频率。这种效应可能是由于通过丘脑皮质上行投射导致前额叶皮质不对称重新激活，进而引起注视系统失衡所致。或者，黑质向上丘的投射中断可能是原因所在。
