Blekher T, Siemers E, Abel L A, Yee R D
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202-5175, USA.
Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2177-83.
To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD).
Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of saccade tasks were used: saccade tasks for eliciting visually guided saccades and saccade tasks for eliciting internally mediated saccades (memory-guided, predictive, and anti-saccades). Latency, accuracy, peak velocity, and other parameters of saccades were evaluated.
Internally mediated saccades were more impaired in patients with advanced PD compared with those with moderate PD. Pallidotomy did not affect visually guided saccades. After pallidotomy, the peak saccadic velocity of internally mediated saccades decreased.
Hence, although pallidotomy has led to improvements in other motor functions, none were observed in saccadic responses. Rather, several modest decrements, below the level of clinical significance and all in internally mediated saccades, were observed.
评估单侧立体定向苍白球腹后切开术对帕金森病（PD）患者眼球扫视运动的影响。
采用红外系统记录31例中重度PD患者在苍白球腹后切开术前1个月及术后3个月的眼球运动。使用两种扫视任务：诱发视觉引导扫视的扫视任务和诱发内源性介导扫视（记忆引导、预测性和反扫视）的扫视任务。评估扫视的潜伏期、准确性、峰值速度及其他参数。
与中度PD患者相比，重度PD患者的内源性介导扫视受损更严重。苍白球腹后切开术不影响视觉引导扫视。苍白球腹后切开术后，内源性介导扫视的峰值速度降低。
因此，尽管苍白球腹后切开术已使其他运动功能得到改善，但在扫视反应方面未观察到改善。相反，观察到一些轻微下降，低于临床意义水平，且均发生在内源性介导扫视中。
