O'Sullivan John D, Maruff Paul, Tyler Peter, Peppard Richard F, McNeill Peter, Currie Jon
Department of Clinical Neuroscience, St Vincent's Hospital, Fitzroy, 3065 Victoria, Australia.
J Clin Neurosci. 2003 Mar;10(2):181-5. doi: 10.1016/s0967-5868(02)00125-x.
Although some motor functions of the basal ganglia have been well studied, the oculomotor functions are not well established. We studied eye movements in patients with Parkinson's disease (PD) undergoing pallidotomy to assess the role of the globus pallidus interna (GPi) in oculomotor control. Horizontal visually guided, gap and predictive saccades as well as ocular fixation were studied in patients with advanced PD before and 1 month after unilateral pallidotomy, and in healthy controls on two occasions 1 month apart. There was no difference in saccadic latency or accuracy, the number of saccadic anticipations or the ability to generate predictive saccades between the two assessments for either patients or controls. The number and amplitude of square wave jerks during ocular fixation however increased significantly in patients after pallidotomy. The results imply altered function of frontal or prefrontal cortical regions involved in ocular fixation resulting from a disruption to inhibitory pallidal influences on thalamocortical projections. The posteroventral GPi however appears not to be involved in externally controlled or predictive saccadic function.
尽管基底神经节的一些运动功能已得到充分研究，但其动眼功能尚未明确。我们研究了接受苍白球切开术的帕金森病（PD）患者的眼球运动，以评估内侧苍白球（GPi）在动眼控制中的作用。对晚期PD患者在单侧苍白球切开术前和术后1个月，以及健康对照者在间隔1个月的两次检查中，研究了水平视觉引导、间隙和预测性扫视以及眼球注视。患者和对照者在两次评估之间的扫视潜伏期或准确性、扫视预期次数或产生预测性扫视的能力均无差异。然而，眼球注视期间的方波急跳次数和幅度在苍白球切开术后的患者中显著增加。结果表明，由于苍白球对丘脑皮质投射的抑制性影响中断，参与眼球注视的额叶或前额叶皮质区域功能发生改变。然而，腹后GPi似乎不参与外部控制或预测性扫视功能。
