Giorgino R, Nardelli G M, Scardapane R
Diabete Metab. 1976 Mar;2(1):11-3.
95 obese subjects, 40 diabetics and 22 normal controls were investigated. The weight of all obese subjects was at least 20% higher than the ideal weight. Catecholamine excretion was determined a few days after hospitalization to minimize the influence of environmental changes. Spectrofluorimetric estimation of adrenaline and noradrenaline in the urine was carried out according to the method of von Euler and Lihajko. Statistical analysis of the results showed a significant increase in both adrenaline and noradrenaline excretion in the group of obeses subjects compared with the diabetics. The increased catecholamine excretion may represent the response of the adrenal medulla to the stress of the disease. Such an increase may be responsible for perpheral insulin resistence and hence acts as a diabetogenic factor. The results obtained emphasize the influence of catecholamines on insulin responsiveness, possibly constituting a major contribution to the diabetic state.
对95名肥胖受试者、40名糖尿病患者和22名正常对照者进行了调查。所有肥胖受试者的体重至少比理想体重高20%。住院几天后测定儿茶酚胺排泄量，以尽量减少环境变化的影响。根据冯·欧拉和利哈伊科的方法对尿液中的肾上腺素和去甲肾上腺素进行荧光分光光度法测定。结果的统计分析表明，与糖尿病患者组相比，肥胖受试者组的肾上腺素和去甲肾上腺素排泄量均显著增加。儿茶酚胺排泄量增加可能代表肾上腺髓质对疾病应激的反应。这种增加可能导致外周胰岛素抵抗，因此是一个致糖尿病因素。所获得的结果强调了儿茶酚胺对胰岛素反应性的影响，可能是导致糖尿病状态的主要因素。
