Latour P, Louis E, Belaiche J
Service de gastroenterologie, CHU, ULG, Sart-Tilman, Liège.
Acta Gastroenterol Belg. 1998 Oct-Dec;61(4):410-3.
A first prospective epidemiological study of IBD was conducted in the area of Liège. The duration of the study was short taking into account the small size of the population (1 million inhabitants). Therefore we carried out a 3 years prospective study.
Private and public gastroenterologists completed a questionnaire for each new case they diagnosed between 01.06.1993 and 31.05.1996.
During that period 270 IBD patients were identified: 137 (51%) had Crohn's disease (CD), 111 (41%) had ulcerative colitis (UC) including 32 proctitis (29% of UC) and 22 (8%) had unclassified colitis. The mean annual incidence per 10(5) was 4.5 for CD and 3.6 for UC. The female/male ratio was 1,6 for CD and 0,5 for UC. The median age at the time of diagnosis was 30 years for CD and 39 years for UC. The mean time between the onset of symptoms and the diagnosis was 6,5 months for CD and only 4,8 months for UC. Family history of IBD was found in 15% of patients with CD and in 7% of UC.
These data show a high incidence of IBD in the area of Liege. These results confirm those reported during the first year of the prospective study which were similar to those observed in North-western France. Contrary to the other countries of Northern Europe, the incidence of UC is lower than the one of CD. Belgium appears to be a privileged country to undertake a national register and to study epidemiological aspects of IBD.
在列日地区开展了首次关于炎症性肠病（IBD）的前瞻性流行病学研究。考虑到该地区人口规模较小（100万居民），研究持续时间较短。因此，我们进行了为期3年的前瞻性研究。
私立和公立胃肠病学家为他们在1993年6月1日至1996年5月31日期间诊断的每一例新病例填写一份问卷。
在此期间，共识别出270例IBD患者：137例（51%）患有克罗恩病（CD），111例（41%）患有溃疡性结肠炎（UC），其中包括32例直肠炎（占UC的29%），22例（8%）患有未分类结肠炎。每10万人中CD的年均发病率为4.5，UC为3.6。CD的女性/男性比例为1.6，UC为0.5。CD诊断时的中位年龄为30岁，UC为39岁。CD症状出现至诊断的平均时间为6.5个月，UC仅为4.8个月。15%的CD患者和7%的UC患者有IBD家族史。
这些数据表明列日地区IBD发病率较高。这些结果证实了前瞻性研究第一年报告的结果，与法国西北部观察到的结果相似。与北欧其他国家相反，UC的发病率低于CD。比利时似乎是开展全国登记并研究IBD流行病学方面的一个得天独厚的国家。
