Reynhout K, Baizer J S
Department of Physiology and Biophysics, University at Buffalo, School of Medicine and Biomedical Sciences, State University of New York, 14214, USA.
Anat Embryol (Berl). 1999 Jan;199(1):75-83. doi: 10.1007/s004290050211.
The claustrum is topographically and reciprocally connected with many different cortical areas, and anatomical and physiological data suggest it is composed of functionally distinct subdivisions. We asked if the distribution of cells immunoreactive for three calcium-binding proteins, parvalbumin, calbindin D-28k and calretinin would delineate functional subdivisions in the claustrum. We also asked if, as in cortex, different cell types were immunoreactive for the different proteins. We found that cells with parvalbumin-ir were large, multipolar cells. Cells immunoreactive for calretinin were bipolar cells with elongated cell bodies and beaded dendrites. There were three different types of cells immunoreactive for calbindin. The most numerous were small cells with round or oval cell bodies and numerous fine, winding processes. A second type were large multipolar, cells that resembled the parvalbumin-ir cells. The third class were bipolar cells with large, elongated cell bodies. Each type of cell resembles a cell type described in earlier Golgi studies, and each has a morphological cortical counterpart. While the different cell types varied in density, each was seen over the anterior-posterior and dorsal-ventral extent of the claustrum.
屏状核在拓扑结构上与许多不同的皮质区域相互连接，解剖学和生理学数据表明它由功能不同的亚区组成。我们询问对三种钙结合蛋白（小白蛋白、钙结合蛋白D-28k和钙视网膜蛋白）免疫反应阳性的细胞分布是否能勾勒出屏状核中的功能亚区。我们还询问，与皮质一样，不同细胞类型对不同蛋白质是否具有免疫反应性。我们发现，对小白蛋白免疫反应阳性的细胞是大的多极细胞。对钙视网膜蛋白免疫反应阳性的细胞是双极细胞，其细胞体细长，树突呈串珠状。对钙结合蛋白免疫反应阳性的细胞有三种不同类型。数量最多的是细胞体呈圆形或椭圆形且有许多细小、蜿蜒突起的小细胞。第二种是大的多极细胞，类似于对小白蛋白免疫反应阳性的细胞。第三类是细胞体大且细长的双极细胞。每种细胞类型都类似于早期高尔基染色研究中描述的细胞类型，并且每种都有形态学上对应的皮质细胞。虽然不同细胞类型的密度有所不同，但在屏状核的前后和背腹范围内都能看到每种细胞。
