Stuen S, Artursson K, Olsson Engvall E
Department of Sheep and Goat Research, Norwegian College of Veterinary Medicine, Sandnes, Norway.
Acta Vet Scand. 1998;39(4):491-7. doi: 10.1186/BF03547775.
Five lambs were inoculated with a granulocytic Ehrlichia species originally isolated from a Swedish horse with granulocytic ehrlichiosis (EGE). The 16S rRNA gene sequence of the Swedish Ehrlichia sp. causing EGE was identical to the sequence of the agent causing human granulocytic ehrlichiosis (HGE). After the inoculation, infected neutrophils and a low serologic response were seen in all lambs, but no clinical symptoms were observed. In one lamb 17% of the neutrophils were infected without a corresponding fever. Six weeks later the lambs were inoculated with an ovine isolate of E. phagocytophila. After challenge with E. phagocytophila the lambs reacted with fever and infected granulocytes. The results presented herein show that the equine Ehrlichia isolate was infective for lambs but generated weak immune response and no distinctive protection from subsequent challenge with E. phagocytophila.
五只羔羊接种了一种最初从患有粒细胞埃立克体病（EGE）的瑞典马身上分离出的粒细胞埃立克体物种。导致EGE的瑞典埃立克体菌株的16S rRNA基因序列与导致人类粒细胞埃立克体病（HGE）的病原体序列相同。接种后，在所有羔羊中均观察到感染的中性粒细胞和低血清学反应，但未观察到临床症状。在一只羔羊中，17%的中性粒细胞被感染，但没有相应的发热症状。六周后，羔羊接种了嗜吞噬细胞埃立克体的绵羊分离株。在用嗜吞噬细胞埃立克体攻击后，羔羊出现发热和感染的粒细胞。本文给出的结果表明，马源埃立克体分离株对羔羊具有感染性，但产生的免疫反应较弱，且对随后的嗜吞噬细胞埃立克体攻击没有明显的保护作用。
