Hoon R S, Sharma S C, Balasubramanian V, Chadha K S, Mathew O P
J Appl Physiol. 1976 Nov;41(5 Pt. 1):631-3. doi: 10.1152/jappl.1976.41.5.631.
Fifty healthy male volunteers, 21-34 yr of age, normally resident at altitudes less than 1,000 m, were airlifted to 3,658 m. Urinary excretion of catecholamines was measured at sea level (198 m) and on the 1st, 2nd, 4th, and 10th day of a stay at high altitude. The symptoms observed on exposure to high altitude were assigned arbitrary scores. The volunteers could, on this basis, be divided into "symptomatic" and "asymptomatic" groups. The two groups showed a markedly different pattern of urinary catecholamines excretion on exposure to high altitude and on return to sea level. Significant increase in the catecholamine excretion was observed in the symptomatic group only. A possible role for enhanced sympathoadrenal activity in the etiopathogenesis of high-altitude illnesses is postulated.
50名年龄在21至34岁之间、通常居住在海拔低于1000米地区的健康男性志愿者被空运至海拔3658米处。在海平面（198米）以及在高海拔停留的第1天、第2天、第4天和第10天测量儿茶酚胺的尿排泄量。将暴露于高海拔时观察到的症状赋予任意分数。据此，志愿者可分为“有症状”组和“无症状”组。两组在暴露于高海拔以及返回海平面时，儿茶酚胺尿排泄模式明显不同。仅在有症状组中观察到儿茶酚胺排泄显著增加。推测交感肾上腺活动增强在高原病发病机制中可能起作用。
