Hoon R S, Sharma S C, Balasubramanian V, Chadha K S
J Appl Physiol Respir Environ Exerc Physiol. 1977 May;42(5):728-30. doi: 10.1152/jappl.1977.42.5.728.
In a preliminary pilot study we had reported a significant difference in urinary catecholamine excretion between symptomatic and asymptomatic individuals inducted to high altitude by air. The present study covers slower induction by road; 25 lowlanders ascended from 1,800 to 3,658 m in 50 h and 33 similar subjects covered the journey in 6 h. They were studied according to the protocal used in the initial study. None of the 58 subjects inducted by road developed symptoms of high-altitude illness. Their urinary catecholamine excretion remained normal during the 10 days' stay at high altitude. These findings lend support to our earlier contention that there might be a relationship between increased sympathoadrenal activity and high-altitude illnesses.
在一项初步的试点研究中，我们报告了通过航空进入高海拔地区的有症状和无症状个体之间尿儿茶酚胺排泄存在显著差异。本研究涵盖了通过公路的较慢诱导过程；25名低地居民在50小时内从1800米上升到3658米，33名类似的受试者在6小时内完成了这段旅程。他们按照最初研究中使用的方案进行研究。通过公路进入的58名受试者中没有一人出现高原病症状。他们在高海拔地区停留的10天内尿儿茶酚胺排泄保持正常。这些发现支持了我们早期的观点，即交感肾上腺活动增加与高原病之间可能存在关联。
