类风湿关节炎（RA）患者体内的高免疫球蛋白E（IgE）与抗IgE自身抗体形成复合物。
High IgE in rheumatoid arthritis (RA) patients is complexed with anti-IgE autoantibodies.
作者信息
Millauer N, Zuercher A W, Miescher S M, Gerber H A, Seitz M, Stadler B M
机构信息
Institute of Immunology and Allergology, University of Bern, Inselspital, Bern, Switzerland.
出版信息
Clin Exp Immunol. 1999 Jan;115(1):183-8. doi: 10.1046/j.1365-2249.1999.00787.x.
This study presents data on more than 300 RA and allergic patients analysed for their serum levels of anti-immunoglobulin isotype autoantibodies and IgE. We observed high levels of IgE in sera of RA and allergic patients. Interestingly, we measured significantly higher specific IgE levels against Alternaria but not against nine other allergens in the RA compared with the allergic group. As expected, anti-IgG autoantibodies (rheumatoid factors (RF)) of different isotypes were detected in sera from RA patients only. However, we found increased titres of complexed anti-IgE autoantibodies in all RF+ groups and in the allergic group. These findings may explain why despite elevated IgE levels a decreased prevalence of allergic diseases in RA patients has been observed.
本研究展示了对300多名类风湿关节炎（RA）患者和过敏患者血清中抗免疫球蛋白同种型自身抗体及IgE水平进行分析的数据。我们观察到RA患者和过敏患者血清中的IgE水平较高。有趣的是，与过敏组相比，我们检测到RA患者血清中针对链格孢属的特异性IgE水平显著更高，但针对其他九种过敏原的特异性IgE水平则无显著差异。正如预期的那样，仅在RA患者的血清中检测到了不同同种型的抗IgG自身抗体（类风湿因子（RF））。然而，我们发现所有RF阳性组和过敏组中复合抗IgE自身抗体的滴度均有所升高。这些发现可能解释了为什么尽管RA患者的IgE水平升高，但观察到其过敏性疾病的患病率却有所下降。
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