Figuerola M L, Loe W, Sormani M, Barontini M
Center for Endocrinological Research, Children's Hospital Ricardo Gutiérrez, Buenos Aires, Argentina.
Funct Neurol. 1998 Oct-Dec;13(4):291-5.
Fibromyalgia is a chronic debilitating condition of unknown etiology. The clinical picture suggests increased activity and/or supersensitivity in nociceptive pathways or inadequate activity in endogenous pain attenuation mechanisms. One therapeutic approach in the treatment of this syndrome is the administration of serial local injections of lidocaine hydrochloride in the painful points. To evaluate the effect of this treatment on plasma met-enkephalin (ME) levels we studied 15 patients, all women with fibromyalgia under local treatment in the tender points, grouped as follows: 5 were treated with local injection of lidocaine hydrochloride, 5 were treated with local injection of saline and 5 treated with dry needling. Significant increases in plasma ME concentrations were observed in all groups in the last sampling of each session studied. These results show an increase in plasma ME levels 10 minutes after finishing each session, which is independent of the maneuver employed.
纤维肌痛是一种病因不明的慢性致残性疾病。临床表现提示伤害感受通路活性增加和/或超敏反应，或内源性疼痛缓解机制活性不足。治疗该综合征的一种方法是在疼痛点连续局部注射盐酸利多卡因。为评估这种治疗对血浆甲硫氨酸脑啡肽（ME）水平的影响，我们研究了15例患者，均为在压痛点接受局部治疗的纤维肌痛女性患者，分组如下：5例接受局部注射盐酸利多卡因治疗，5例接受局部注射生理盐水治疗，5例接受干针治疗。在研究的每个疗程的最后一次采样中，所有组的血浆ME浓度均显著升高。这些结果表明，在每个疗程结束10分钟后血浆ME水平升高，这与所采用的操作无关。
