Nezu R, Takagi Y, Ito T, Matsuda H, Okada A
First Department of Surgery, Osaka University Medical School, Suita, Japan.
Surg Today. 1999;29(1):34-41. doi: 10.1007/BF02482967.
It is well known that zinc (Zn), an essential trace element, plays a role in wound healing. Although the importance of Zn supplementation in total parenteral nutrition (TPN) has been recognized, the difference in tissue Zn distribution induced by TPN and whether this difference influences local wound healing remains uncertain. Thus, we conducted a study using 30 Sprague-Dawley rats to investigate the influence of TPN-induced changes in tissue Zn distribution on wound healing at sites of intestinal anastomosis, muscle, and skin sutures. In the ordinary diet group, no significant differences were observed between subgroups with and without supplemental Zn in tissue Zn distribution or in the healing of intestinal, muscular, and cutaneous wounds. In the subgroup given a low-protein diet without supplemental Zn, a gross change in tissue Zn distribution was noted to occur with a concomitant marked decrease in Zn concentration and the tensile strength of wounded skin. These results indicate an association between wound healing and Zn concentration in the respective tissues in TPN-induced Zn deficiency with alternations in tissue Zn distribution. They also provide evidence of the local action of Zn in wound healing.
众所周知，锌（Zn）作为一种必需的微量元素，在伤口愈合中发挥作用。尽管在全肠外营养（TPN）中补充锌的重要性已得到认可，但TPN引起的组织锌分布差异以及这种差异是否会影响局部伤口愈合仍不确定。因此，我们使用30只Sprague-Dawley大鼠进行了一项研究，以探讨TPN诱导的组织锌分布变化对肠吻合口、肌肉和皮肤缝合部位伤口愈合的影响。在普通饮食组中，补充锌和未补充锌的亚组之间在组织锌分布或肠、肌肉和皮肤伤口愈合方面未观察到显著差异。在给予低蛋白饮食且未补充锌的亚组中，注意到组织锌分布发生了明显变化，同时受伤皮肤的锌浓度和抗张强度显著降低。这些结果表明，在TPN诱导的锌缺乏伴组织锌分布改变的情况下，伤口愈合与各组织中的锌浓度之间存在关联。它们还提供了锌在伤口愈合中局部作用的证据。
