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冠状动脉搭桥手术与经皮腔内冠状动脉成形术后三年生存率的比较。

A comparison of three-year survival after coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty.

作者信息

Hannan E L, Racz M J, McCallister B D, Ryan T J, Arani D T, Isom O W, Jones R H

机构信息

Department of Health Policy, Management, and Behavior, State University of New York, Rensselaer 12144-3456, USA.

出版信息

J Am Coll Cardiol. 1999 Jan;33(1):63-72. doi: 10.1016/s0735-1097(98)00540-3.

Abstract

OBJECTIVES

The purpose of this study was to compare 3-year risk-adjusted survival in patients undergoing coronary artery bypass graft (CABG) surgery and percutaneous transluminal coronary angioplasty.

BACKGROUND

Coronary artery bypass graft surgery and angioplasty are two common treatments for coronary artery disease. For referral purposes, it is important to know the relative pattern of survival after hospital discharge for these procedures and to identify patient characteristics that are related to survival.

METHODS

New York's CABG surgery and angioplasty registries were used to identify New York patients undergoing CABG surgery and angioplasty from January 1, 1993 to December 31, 1995. Mortality within 3 years of undergoing the procedure (adjusted for patient severity of illness) and subsequent revascularization within 3 years were captured. Three-year mortality rates were adjusted using proportional hazards methods to account for baseline differences in patients' severity of illness.

RESULTS

Patients with one-vessel disease with the one vessel not involving the left anterior descending artery (LAD) or with less than 70% LAD stenosis had a statistically significantly longer adjusted 3-year survival with angioplasty (95.3%) than with CABG surgery (92.4%). Patients with proximal LAD stenosis of at least 70% had a statistically significantly longer adjusted 3-year survival with CABG surgery than with angioplasty regardless of the number of coronary vessels diseased. Also, patients with three-vessel disease had a statistically significantly longer adjusted 3-year survival with CABG surgery regardless of proximal LAD disease. Patients with other one-vessel or two-vessel disease had no treatment-related differences in survival.

CONCLUSIONS

Treatment-related survival benefit at 3-years in patients with ischemic heart disease is predicted by the anatomic extent and specific site of the disease, as well as by the treatment chosen.

摘要

目的

本研究旨在比较接受冠状动脉旁路移植术(CABG)和经皮冠状动脉腔内血管成形术的患者3年风险调整后的生存率。

背景

冠状动脉旁路移植术和血管成形术是冠状动脉疾病的两种常见治疗方法。为了便于转诊,了解这些手术后出院后的相对生存模式以及识别与生存相关的患者特征非常重要。

方法

利用纽约的CABG手术和血管成形术登记处,确定1993年1月1日至1995年12月31日在纽约接受CABG手术和血管成形术的患者。记录手术3年内的死亡率(根据患者疾病严重程度进行调整)以及3年内随后的血运重建情况。使用比例风险方法调整3年死亡率,以考虑患者疾病严重程度的基线差异。

结果

单支血管病变且该血管不涉及左前降支(LAD)或LAD狭窄小于70%的患者,血管成形术调整后的3年生存率(95.3%)在统计学上显著长于CABG手术(92.4%)。无论病变冠状动脉血管数量如何,LAD近端狭窄至少70%的患者,CABG手术调整后的3年生存率在统计学上显著长于血管成形术。此外,无论LAD近端病变如何,三支血管病变的患者CABG手术调整后的3年生存率在统计学上显著更长。其他单支血管或双支血管病变的患者在生存方面没有与治疗相关的差异。

结论

缺血性心脏病患者3年的治疗相关生存获益可通过疾病的解剖范围、特定部位以及所选治疗方法来预测。

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