Ognjenović M, Karelović D, Cindro V V, Tadin I
Clinical Hospital Split, Department of Obstetric and Gynecology, Croatia.
Coll Antropol. 1998 Dec;22 Suppl:89-92.
Oral lichen planus (OLP) is autoimmune disease that appears on the oral mucosa only, or in combination with skin lesions. The occurrence of squamous cell carcinoma in areas of lichen erosions makes it necessary to follow up patients suffering from chronic lesions. Prevalence in general population varies from 0.9% to 1.2% and varies in different ethnic groups. It is known that cell-mediated immune mechanisms and genetic factors underline OLP pathogenesis. We tested 50 OLP unrelated patients (5 males) for HLA A and compared them to 1089 healthy controls. OLP patients had 3 times less frequently HLA A w19 and 5 times less frequently HLA A28, compared with controls. Erosive OLP type had 4 times less frequently HLA A11 and 2 times less frequently HLA A26 than plaque form. In conclusion, HLA A w19 and A28 appeared associated with OLP in particular, while HLA A11 and A26 with erosive types of OLP.
口腔扁平苔藓（OLP）是一种仅出现在口腔黏膜或伴有皮肤损害的自身免疫性疾病。在苔藓糜烂区域发生鳞状细胞癌使得对患有慢性损害的患者进行随访成为必要。普通人群中的患病率在0.9%至1.2%之间，且在不同种族群体中有所不同。已知细胞介导的免疫机制和遗传因素是OLP发病机制的基础。我们对50例无亲属关系的OLP患者（5名男性）进行了HLA A检测，并将他们与1089名健康对照者进行比较。与对照组相比，OLP患者中HLA A w19的出现频率低3倍，HLA A28的出现频率低5倍。糜烂型OLP中HLA A11的出现频率比斑块型低4倍，HLA A26的出现频率比斑块型低2倍。总之，HLA A w19和A28尤其与OLP相关，而HLA A11和A26与糜烂型OLP相关。
