Ognjenović M, Karelović D, Mikelić M, Tadin I, Vrebalov-Cindro V
Clinical Hospital Split, Department of Obstetric and Gynecology, Croatia.
Coll Antropol. 1998 Dec;22 Suppl:93-6.
Oral lichen planus (OLP) is mucocutaneous autoimmune disease of still unknown etiology. Among all etiological factors, OLP can be associated with carbohydrate disorders. As it is known that some HLA B and DR 3/4 antigens are cross-linked, we have determined the frequencies of HLA B antigens in group of 50 Croatian patients (5 males) with OLP and compared them with the 1089 healthy controls. Alterations in the frequencies of several HLA B antigens were noted, in particular, the frequencies of HLA B 15 were 4 times higher, and HLA B18 were 4 times lower compared with controls. The OLP patients with carbohydrate metabolism disorders had more frequently HLA B16, B2 and B40 and the patients with OLP without disturbed carbohydrate metabolism had more frequently HLA B5, B7 and BX. HLA B15 and B18 are closely connected with DR 3/4 antigens in diabetes mellitus, so these particular antigens may predispose a person to a lichen planus.
口腔扁平苔藓（OLP）是一种病因仍不明的黏膜皮肤自身免疫性疾病。在所有病因中，OLP可能与碳水化合物代谢紊乱有关。由于已知某些HLA B和DR 3/4抗原存在交叉关联，我们测定了50名克罗地亚OLP患者（5名男性）群体中HLA B抗原的频率，并将其与1089名健康对照者进行比较。发现几种HLA B抗原的频率存在改变，特别是与对照相比，HLA B 15的频率高出4倍，而HLA B18的频率低4倍。碳水化合物代谢紊乱的OLP患者更常出现HLA B16、B2和B40，而无碳水化合物代谢紊乱的OLP患者更常出现HLA B5、B7和BX。HLA B
