Hartmann E, Zwilling G
Pharmacol Biochem Behav. 1976 Aug;5(2):135-8. doi: 10.1016/0091-3057(76)90028-9.
We investigated the effects of the beta adrenergic blocker, propranolol, and the alpha adrenergic blocker, phenoxybenzamine, on sleep patterns in the rat by means of multiple 8-hr and 24-hr polygraphic recordings. Propranolol had no clear effect on time spent in waking, synchronized sleep or desynchronized sleep. Phenoxybenzamine at a dose of 40 mg/kg produced a significant increase in desynchronized sleep time and in the number of desynchronized sleep periods. This is consistent with the view that there may be a mechanism inhibiting the onset of desynchronized sleep periods which involves norepinephrine acting at alpha adrenergic receptors in the brain.
我们通过多次8小时和24小时的多导记录，研究了β肾上腺素能阻滞剂普萘洛尔和α肾上腺素能阻滞剂酚苄明对大鼠睡眠模式的影响。普萘洛尔对清醒、同步睡眠或去同步睡眠所花费的时间没有明显影响。剂量为40mg/kg的酚苄明使去同步睡眠时间和去同步睡眠周期数显著增加。这与以下观点一致，即可能存在一种抑制去同步睡眠周期开始的机制，该机制涉及去甲肾上腺素作用于大脑中的α肾上腺素能受体。
