Piller N B
Res Exp Med (Berl). 1976 Oct 29;168(3):165-72. doi: 10.1007/BF01851314.
The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the number of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.
本文所提供的证据表明香豆素是一种网状内皮系统（RES）刺激剂。在30分钟时或之前就观察到RPP（相对血浆蛋白）和放射性RPVP（放射性血浆容积）的清除增强，且持续长达6小时。在这段时间内，RPP的清除平均增强了40%，而RPVP的清除增强了60%。由于RPVP是不可代谢的，其水平可能是香豆素刺激作用更准确的估计指标。这一证据与之前的结果非常吻合，之前的结果表明香豆素可能会增加吞噬细胞的数量。其他结果显示，在相似时间段内蛋白质裂解增强了74%，同时观察到蛋白酶活性水平增强了50%。
