Barltrop D, Khoo H E
Sci Total Environ. 1976 Nov;6(3):265-73. doi: 10.1016/0048-9697(76)90036-x.
The nutritional factors influencing the absorption of lead from the gut have been studied using both intact animals and ligated gut loop preparation. Short-term feeding studies have been made in groups of six animals using diets of constant lead content (0.075%) but in which the nutritional components were varied sequentially. Dietary lead was labelled with 203Pb. Absorption was determined in the carcass and individual organs by means of a small-animal wholebody counter. The results showed that absorption was enhanced to twenty-times control value by diets deficient in minerals and seven-fold by diets of high fat content. Conversely, high mineral diets have been shown to result in a two-fold reduction in lead absorption. The interaction of lead with individual dietary components has been further studied under controlled conditions using ligated gut loop preparations. Using this technique the relative roles of luminal interaction and tissue response for lead absorption have been explored and the kinetics of lead absorption determined.
利用完整动物和结扎肠袢制备方法，对影响肠道铅吸收的营养因素进行了研究。采用短期喂养研究，将六只动物分为一组，使用铅含量恒定（0.075%）但营养成分依次变化的日粮。日粮中的铅用²⁰³Pb标记。通过小动物全身计数器测定胴体和各个器官中的铅吸收情况。结果表明，矿物质缺乏的日粮可使铅吸收增强至对照值的20倍，高脂肪日粮可使其增强7倍。相反，高矿物质日粮已被证明可使铅吸收降低两倍。在可控条件下，利用结扎肠袢制备方法进一步研究了铅与个别日粮成分的相互作用。利用该技术，探讨了肠腔相互作用和组织反应对铅吸收的相对作用，并确定了铅吸收的动力学。
