Patrick J
Pediatr Res. 1978 Jul;12(7):767-70. doi: 10.1203/00006450-197807000-00005.
Leukocyte potassium has been measured in normal subjects and in malnourished children with and without edema both on admission and during recovery. In nonedematous malnourished children the potassium content was low (328 mmol/kg dry solids) and took 2-3 weeks of rehabilitation to return to normal (374 mmol/kg dry solids). Leukocytes from edematous children had normal intracellular potassium values. However, 5 days on a maintenance diet reduced the intracellular potassium in the children with kwashiorkor to a value similar to that found in marasmus. Plasma potassium was significantly lower in kwashiorkor (3.43) than in marasmus (4.74), The relationship between external potassium and internal potassium in normal leukocytes was measured (Fig. 1) and the values found in severe malnutrition compared with normal. It was found that in nonedematous malnutrition intracellular potassium was low compared to the predicted value, whereas in kwashiorkor, although the mean values were normal, no relationship between external potassium and intracellular potassium could be domonstrated. It is concluded that in the leukocyte malnutrition alters either the passive permeability of the membrane to potassium or the active transport of potassium, or both.
已对正常受试者以及患有和未患水肿的营养不良儿童在入院时和康复期间的白细胞钾含量进行了测量。在无水肿的营养不良儿童中，钾含量较低（328 mmol/kg干物质），需要2至3周的康复时间才能恢复正常（374 mmol/kg干物质）。水肿儿童的白细胞细胞内钾值正常。然而，接受维持性饮食5天后，夸希奥科病患儿的细胞内钾含量降至与消瘦症患儿相似的值。夸希奥科病患儿的血浆钾（3.43）明显低于消瘦症患儿（4.74）。测量了正常白细胞中外源钾与内源钾之间的关系（图1），并将严重营养不良时的值与正常情况进行了比较。结果发现，在无水肿的营养不良中，细胞内钾低于预测值，而在夸希奥科病中，尽管平均值正常，但未显示外源钾与细胞内钾之间的关系。结论是，在白细胞中，营养不良会改变细胞膜对钾的被动通透性或钾的主动转运，或两者皆有改变。
