信使核糖核酸丰度与寿命：在果蝇细胞中存在相关性，但在HeLa细胞中不存在。
Messenger RNA abundance and lifetime: a correlation in Drosophila cells but not in HeLa.
作者信息
Lenk R, Herman R, Penman S
出版信息
Nucleic Acids Res. 1978 Aug;5(8):3057-70. doi: 10.1093/nar/5.8.3057.
Abstract
Messenger RNA in eukaryotes is comprised of several abundance classes. Also, the decay of these unstable molecules shows at least two very different lifetimes. Two independent techniques are used here to examine the relation between message abundance and lifetime in cell lines from very different organisms. The methods give consistent results for each cell line; however, the two cell types show very different results. In brosophile cells, slowly decaying sequences fall in the abundant class while scarce sequences turn over rapidly. In contrast, in HeLa cells the abundant and scarce message classes are each comprised of long- and short-lived molecules.
摘要
真核生物中的信使核糖核酸由几个丰度类别组成。此外，这些不稳定分子的衰变表现出至少两种非常不同的寿命。这里使用两种独立的技术来研究来自非常不同生物体的细胞系中信使丰度与寿命之间的关系。对于每个细胞系，这些方法给出了一致的结果；然而，这两种细胞类型显示出非常不同的结果。在嗜热栖热菌细胞中，缓慢衰变的序列属于丰富类别，而稀少的序列快速周转。相比之下，在海拉细胞中，丰富和稀少的信使类别均由长寿命和短寿命分子组成。
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