Hall B G
University of Rochester, Rochester, New York.
J Bacteriol. 1999 Feb;181(4):1149-55. doi: 10.1128/JB.181.4.1149-1155.1999.
A comparison of the spectra of spontaneous growth-dependent and adaptive mutations in ebgR shows that both spectra are dominated by insertion sequence (IS)-mediated mutations. The difference between growth-dependent mutations (61% IS mediated) and adaptive mutations (80% IS mediated) is highly significant (P < 0.0001). In contrast, the spectra of growth-dependent and adaptive non-IS-mediated mutations do not differ from each other and therefore do not provide support for the hypothesis that adaptive and growth-dependent mutations arise by substantially different mechanisms.
对ebgR中自发的生长依赖性突变和适应性突变的光谱比较表明，这两种光谱均以插入序列（IS）介导的突变为主要特征。生长依赖性突变（61%由IS介导）和适应性突变（80%由IS介导）之间的差异非常显著（P < 0.0001）。相比之下，生长依赖性和适应性非IS介导的突变光谱彼此没有差异，因此不支持适应性突变和生长依赖性突变通过实质上不同的机制产生这一假设。
