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从感染人类免疫缺陷病毒的患者中分离出的两个地理分布不同的白色念珠菌样本之间缺乏基因分化。

Lack of genetic differentiation between two geographically diverse samples of Candida albicans isolated from patients infected with human immunodeficiency virus.

作者信息

Xu J, Vilgalys R, Mitchell T G

机构信息

Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

出版信息

J Bacteriol. 1999 Feb;181(4):1369-73. doi: 10.1128/JB.181.4.1369-1373.1999.

Abstract

The patterns of genetic variation of samples of Candida albicans isolated from patients infected with human immunodeficiency virus in Durham, N.C., and Vitória, Brazil, were compared. Genotypes for 126 strains were obtained at 16 polymorphic restriction sites distributed on nine PCR fragments. The results indicated evidence of clonality both within and between these two geographically diverse samples. The samples are genetically very similar, with little evidence of genetic differentiation.

摘要

对从美国北卡罗来纳州达勒姆市和巴西维多利亚市感染人类免疫缺陷病毒的患者中分离出的白色念珠菌样本的遗传变异模式进行了比较。在分布于9个PCR片段上的16个多态性限制性位点获得了126株菌株的基因型。结果表明,在这两个地理上不同的样本内部和之间都有克隆性的证据。这些样本在基因上非常相似,几乎没有遗传分化的证据。

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