Pujol C, Reynes J, Renaud F, Raymond M, Tibayrenc M, Ayala F J, Janbon F, Mallié M, Bastide J M
Laboratoire d'Immunologie et Parasitologie, Faculté de Pharmacie, Montpellier, France.
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9456-9. doi: 10.1073/pnas.90.20.9456.
To ascertain the population structure of Candida albicans, we have carried out a multilocus enzyme electrophoresis study based on the analysis of 21 gene loci. We have thus characterized 55 strains isolated one each from 55 human immunodeficiency virus-positive patients. There is considerable polymorphism among the strains. A population-genetic analysis indicates that the two fundamental consequences of sexual reproduction (i.e., segregation and recombination) are apparently absent in this population of C. albicans. The population structure of C. albicans appears to be clonal, a state of affairs that has important medical and biological consequences.
为了确定白色念珠菌的种群结构，我们基于对21个基因位点的分析开展了一项多位点酶电泳研究。我们由此对从55名人类免疫缺陷病毒阳性患者中分别分离出的55株菌株进行了特征描述。这些菌株之间存在相当大的多态性。一项种群遗传学分析表明，有性繁殖的两个基本结果（即分离和重组）在该白色念珠菌种群中显然不存在。白色念珠菌的种群结构似乎是克隆性的，这种情况具有重要的医学和生物学意义。
