Pistelli F, Di Pede F, Viegi G, Carrozzi L, Pistelli G, Giuntini C
CNR Institute of Clinical Physiology and Cardiovascular and Pulmonary Department, University and Hospital of Pisa, Italy.
Respiration. 1999;66(1):34-40. doi: 10.1159/000029334.
The aim of this study was to evaluate whether the intrasession reproducibility of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) depends on height and lung volume. FVC tracings of 740 subjects (350 males) from a general population sample living in North Italy were analyzed. Subjects filled out a standardized questionnaire and performed three acceptable FVC maneuvers following the American Thoracic Society recommendations. The differences between the largest and the second largest FVC and FEV1 were computed as absolute (DeltaFVC, DeltaFEV1) and as percentage values (DeltaFVC%, DeltaFEV1%). The higher the tertiles of the largest FVC and FEV1 were, the higher were DeltaFVC and DeltaFEV1. Regarding FVC, borderline differences in both sexes for DeltaFVC and in males significant differences for DeltaFVC% were found among the tertiles. Regarding FEV1, in both sexes DeltaFEV1 significantly differed among the tertiles. DeltaFVC and DeltaFEV1 correlated with height and lung volume in both sexes, except for DeltaFVC versus the largest FVC in females. When DeltaFVC and DeltaFEV1 were analyzed with respect to respiratory symptoms/diseases and smoking habit, no significant differences were observed in both sexes, except for DeltaFEV1 between ever- and never-smoking males. It may be concluded that the intrasession within-subject variability of FVC and FEV1 is proportional to lung volume and height, regardless of the sex, presence of symptoms and smoking habit. Thus, our results confirm the usefulness of a reproducibility criterion based on a percentage rather than on a fixed volume.
本研究的目的是评估用力肺活量（FVC）和第1秒用力呼气量（FEV1）的日内重复性是否取决于身高和肺容积。对来自意大利北部普通人群样本的740名受试者（350名男性）的FVC描记图进行了分析。受试者填写了一份标准化问卷，并按照美国胸科学会的建议进行了三次可接受的FVC操作。计算最大FVC与第二大FVC以及FEV1之间的差异，以绝对值（ΔFVC、ΔFEV1）和百分比值（ΔFVC%、ΔFEV1%）表示。最大FVC和FEV1的三分位数越高，ΔFVC和ΔFEV1越高。关于FVC，在三分位数之间，男女在ΔFVC方面存在临界差异，男性在ΔFVC%方面存在显著差异。关于FEV1，男女在三分位数之间的ΔFEV1均存在显著差异。除女性中ΔFVC与最大FVC的关系外，男女的ΔFVC和ΔFEV1均与身高和肺容积相关。当分析ΔFVC和ΔFEV1与呼吸道症状/疾病及吸烟习惯的关系时，除曾经吸烟和从不吸烟的男性之间的ΔFEV1外，男女均未观察到显著差异。可以得出结论，FVC和FEV1的日内受试者内变异性与肺容积和身高成正比，与性别、症状的存在和吸烟习惯无关。因此，我们的结果证实了基于百分比而非固定容积的重复性标准的实用性。
