急性粒单核细胞白血病中均匀染色区的跳跃易位及伴有双微体的四倍体现象

Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia.

作者信息

Yoshida T, Kimura N, Akiyoshi T, Ohshima K, Nagano M, Morioka E, Hisano S, Ohyashiki K, Kamada N, Tamura K

机构信息

First Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.

出版信息

Cancer Genet Cytogenet. 1999 Feb;109(1):40-4. doi: 10.1016/s0165-4608(98)00144-7.

DOI:10.1016/s0165-4608(98)00144-7

PMID:9973958

Abstract

We report a 71-year-old patient with acute myelomonocytic leukemia (AMMoL) who had complicated chromosomal abnormalities showing diploidy with a jumping translocation of a homogeneously staining region (hsr) and tetraploidy with double minutes (dmin). The analysis of gene amplification showed that hsr and dmin were the results of C-ETS 1 gene amplification. After induction chemotherapy, tetraploidy with dmin completely disappeared, while diploidy with hsr and del(11)(q23) remained until the patient died. It is speculated that hsr is more stable than dmin during chemotherapy and that the presence of tetraploidy is not necessarily a factor of poor response to chemotherapy for acute leukemia.

摘要

我们报告了一名71岁的急性粒单核细胞白血病（AMMoL）患者，其存在复杂的染色体异常，表现为二倍体伴均匀染色区（hsr）的跳跃易位以及四倍体伴双微体（dmin）。基因扩增分析显示，hsr和dmin是C-ETS 1基因扩增的结果。诱导化疗后，四倍体伴dmin完全消失，而二倍体伴hsr和del(11)(q23)一直存在直至患者死亡。据推测，hsr在化疗期间比dmin更稳定，并且四倍体的存在不一定是急性白血病化疗反应不佳的因素。