Fossan G O, Aarli J A
Eur Neurol. 1979;18(5):322-7. doi: 10.1159/000115096.
Concentrations of IgG and titres of IgG antibodies to rabbit erythrocytes were studied in serum and cerebrospinal fluid (CSF) from 21 phenytoin-treated patients; 11 of these had reduced serum IgA. The CSF IgG concentration was not reduced in any patient. A reduction of CSF IgG has been found earlier in phenytoin-treated patients, when other antisera to IgG were used for the determination of IgG concentration. The present findings therefore indicate that an alteration of the composition or quality of the CSF IgG is present in phenytoin-treated patients. 1 patient had a phenytoin-induced low serum concentration of IgG and IgA. In this patient the ratios CSF:serum were normal both for IgG concentration and for IgG antibodies to rabbit erythrocytes.
研究了21例接受苯妥英治疗患者的血清和脑脊液（CSF）中IgG浓度及抗兔红细胞IgG抗体滴度；其中11例患者血清IgA降低。所有患者的脑脊液IgG浓度均未降低。早期使用其他抗IgG血清测定IgG浓度时，曾发现接受苯妥英治疗的患者脑脊液IgG降低。因此，目前的研究结果表明，接受苯妥英治疗的患者脑脊液IgG的组成或质量发生了改变。1例患者出现苯妥英诱导的血清IgG和IgA浓度降低。该患者脑脊液与血清中IgG浓度及抗兔红细胞IgG抗体的比值均正常。
