Malone J I, Rosenbloom A L, Grgic A, Weber F T
Am J Dis Child. 1976 Dec;130(12):1324-7. doi: 10.1001/archpedi.1976.02120130030006.
The concentration of reducing sugar in the urine is commonly used in the management of diabetes in children. Supplemental doses of regular insulin are administered in response to the concentration of urine sugar according to a protocol termed the "sliding scale." This practice assumes that the concentration of sugar in urine is a good indicator of the plasma glucose concentration. This assumption was tested by comparing urine sugar concentrations in first and second voided urines with the plasma glucose concentrations in 220 children with diabetes. The correlation was good (r = .92) for both the first and second voided urine specimens. Thus, urine sugar concentrations in general define the level of plasma glucose. The large standard deviation of the plasma glucose at each concentration of urine sugar, however, limits the usefulness of urine sugar as an accurate reflection of the coincident plasma glucose concentration. The urine sugar concentration, although useful for the general management of diabetes, provides significant risk when used to guide frequent adjustments in insulin administration. Therefore, the "sliding scale" should not be used in the treatment of children with diabetes.
尿中还原糖的浓度常用于儿童糖尿病的管理。根据一种称为“血糖滑动剂量表”的方案，根据尿糖浓度给予补充剂量的常规胰岛素。这种做法假定尿糖浓度是血浆葡萄糖浓度的良好指标。通过比较220名糖尿病儿童首次排尿和第二次排尿的尿糖浓度与血浆葡萄糖浓度，对这一假设进行了检验。首次排尿和第二次排尿的尿液标本的相关性都很好（r = 0.92）。因此，尿糖浓度总体上可确定血浆葡萄糖水平。然而，在每个尿糖浓度下血浆葡萄糖的标准差较大，限制了尿糖作为同时期血浆葡萄糖浓度准确反映指标的实用性。尿糖浓度虽然对糖尿病的一般管理有用，但用于指导频繁调整胰岛素给药时存在重大风险。因此，“血糖滑动剂量表”不应应用于糖尿病儿童的治疗。
